About the Authors

Alex J. Mann

a.mann@retroscreen.com

Affiliation Retroscreen Virology, London, United Kingdom

Nicolas Noulin

Affiliation Retroscreen Virology, London, United Kingdom

Andrew Catchpole

Affiliation Retroscreen Virology, London, United Kingdom

Koert J. Stittelaar

Affiliation Viroclinics Biosciences BV, Rotterdam, Netherlands

Leon de Waal

Affiliation Viroclinics Biosciences BV, Rotterdam, Netherlands

Edwin J. B. Veldhuis Kroeze

Affiliation Viroclinics Biosciences BV, Rotterdam, Netherlands

Michael Hinchcliffe

Current address: Paracelsis Ltd, Nottingham, United Kingdom

Affiliation Archimedes Development Limited, Nottingham, United Kingdom

Alan Smith

Affiliation Archimedes Development Limited, Nottingham, United Kingdom

Emanuele Montomoli

Affiliations University of Siena, Siena, Italy, VisMederi LifeSciences, srl, Siena, Italy

Simona Piccirella

Affiliation VisMederi LifeSciences, srl, Siena, Italy

Albert D. M. E. Osterhaus

Affiliations Viroclinics Biosciences BV, Rotterdam, Netherlands, Department of Viroscience, Erasmus MC, Rotterdam, Netherlands

Alastair Knight

Affiliation Evicom, Teddington, United Kingdom

John S. Oxford

Affiliation Retroscreen Virology, London, United Kingdom

Giulia Lapini

Affiliation University of Siena, Siena, Italy

Rebecca Cox

Affiliations Department of Clinical Science, University of Bergen, Bergen, Norway, Department of Research and Development, Haukeland University Hospital, Bergen, Norway

Rob Lambkin-Williams

Affiliation Retroscreen Virology, London, United Kingdom

Competing Interests

At the time of the study: AJM, NN, AC, RLW were employees of Retroscreen Virology Ltd. JSO was President, Scientific Director of Retroscreen Virology Ltd. and an employee of Queen Mary College, London. MH and AS were employees of Archimedes Development Limited. KJS, EJBVK, LdW, GvA and ADMEO were employees of ViroClinics Biosciences BV. ADMEO was chief scientific officer of ViroClinics Biosciences BV. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Additionally as requested by the journal the authors request to also add the following conflicts that applied at the time of the study: AK was an employee of Evicom, Teddington, United Kingdom. Again, this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AJM RLW AC KJS ADMEO MH AS. Performed the experiments: KJS LdW EJBVK GL SP EM. Analyzed the data: AJM AK NN KJS LdW EJBVK ADMEO RLW. Wrote the paper: AJM RLW JSO. Immunology work package leader for FP7 grant: RC. Manufacture and supply of vaccines: MH AS.