About the Authors

Mahvash Shere

Affiliations Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Toronto, Ontario, Canada

Xiu Yan Zhao

Affiliation Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada

Gideon Koren

gkoren@sickkids.ca

Affiliations Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Toronto, Ontario, Canada

Competing Interests

The clinical trial associated with this study was funded by Duchesnay Inc., Blainville, Quebec, Canada. Duchesnay supplied the prenatal multivitamins used in the study to assess steady-state folate pharmacokinetics with a regular vs. high dose of folic acid. There are no other patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MS GK. Performed the experiments: MS. Analyzed the data: MS XYZ. Contributed reagents/materials/analysis tools: MS XYZ. Wrote the paper: MS GK. Helped with writing the time-series methodology: MS XYZ.