Sequencing and Characterisation of Rearrangements in Three S. pastorianus Strains Reveals the Presence of Chimeric Genes and Gives Evidence of Breakpoint Reuse

Sarah K. Hewitt; Ian J. Donaldson; Simon C. Lovell; Daniela Delneri

doi:10.1371/journal.pone.0092203

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Open Access

Peer-reviewed

Research Article

Sequencing and Characterisation of Rearrangements in Three S. pastorianus Strains Reveals the Presence of Chimeric Genes and Gives Evidence of Breakpoint Reuse

Sarah K. Hewitt,

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Ian J. Donaldson,

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Simon C. Lovell,

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Daniela Delneri

* E-mail: d.delneri@manchester.ac.uk

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯

Sequencing and Characterisation of Rearrangements in Three S. pastorianus Strains Reveals the Presence of Chimeric Genes and Gives Evidence of Breakpoint Reuse

Sarah K. Hewitt,
Ian J. Donaldson,
Simon C. Lovell,
Daniela Delneri

Published: March 18, 2014
https://doi.org/10.1371/journal.pone.0092203

About the Authors

Sarah K. Hewitt

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Ian J. Donaldson

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Simon C. Lovell

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Daniela Delneri

* E-mail: d.delneri@manchester.ac.uk

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DD SKH. Performed the experiments: SKH. Analyzed the data: SKH IJD SCL DD. Contributed reagents/materials/analysis tools: SCL DD. Wrote the paper: SKH IJD SCL DD.

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Saccharomyces cerevisiae
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Genomics
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Chimeric genes
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Yeast
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Chromosome mapping
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Nucleotide sequencing
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Polymerase chain reaction
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Sequence alignment
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