About the Authors

Arja Helin-Salmivaara

arja.helin-salmivaara@utu.fi

Affiliations Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland, Unit of Primary Health Care, Hospital District of Helsinki and Uusimaa, Helsinki, Finland

Piia Lavikainen

Affiliation Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Emma Aarnio

Affiliations Department of Clinical Pharmacology, Tykslab, Turku University Hospital, Turku, Finland, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

Risto Huupponen

Affiliations Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland, Department of Clinical Pharmacology, Tykslab, Turku University Hospital, Turku, Finland

Maarit Jaana Korhonen

Affiliations Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland, Department of Public Health, University of Turku, Turku, Finland

Competing Interests

The authors have read the journal's policy and have the following conflicts: AHS, MK and RH have been funded by the grants from the Social Insurance Institution and the Academy of Finland. EA was supported by state funding for university-level health research (Grant L 3820). She has received consultancy fees from ESiOR Ltd, which provides health economic and outcomes research services for pharmaceutical companies and hospitals. RH is a member of the Advisory Board for Social and Medical Affairs of the SII. He has conducted consultancy for Orion Corporation as an Independent External Member of a Data Monitoring and Safety Committee in a clinical trial, and assisted Santen Pharmaceutical Co in pharmacokinetic calculations. The authors declare no other financial or non-financial (professional or personal) conflict of interests. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AHS PL EA MK RH. Analyzed the data: AHS MK. Wrote the paper: AHS PL EA MK RH.