About the Authors

Andre S. Nell

Affiliation PAREXEL Early Phase Clinical Unit, Bloemfontein, South Africa

Eva D’lom

Affiliation PAREXEL International, Madrid, Spain

Patrick Bouic

Affiliation Synexa Life Sciences, Cape Town, South Africa

Montserrat Sabaté

Affiliation TFS Develop, Barcelona, Catalonia, Spain

Ramon Bosser

Affiliation Janus Developments, Barcelona, Catalonia, Spain

Jordi Picas

Affiliation Archivel Farma, Badalona, Catalonia, Spain

Mercè Amat

Affiliation Archivel Farma, Badalona, Catalonia, Spain

Gavin Churchyard

Affiliation The Aurum Institute, Johannesburg, South Africa

Pere-Joan Cardona

pj.cardona@gmail.com

Affiliations Archivel Farma, Badalona, Catalonia, Spain, Unitat de Tuberculosi Experimental (UTE), Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain

Competing Interests

The following statement was included in the cover letter: Jordi Picas and Mercè Amat are employees of Archivel Farma S.L., Pere-Joan Cardona is consultant of Archivel Farma S.L., Andre S. Nell and Eva D’lom are employees of PAREXEL (South Africa) and PAREXEL International (Spain), respectively. Patrick Bouic is employee of Synexa Life Sciences (SouthAfrica), Ramon Bosser is employee of Janus Developments (Spain), and Montserrat Sabaté is an employee of TFS Develop (Spain). This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. Pere Joan Cardona is editor of PLOS ONE. The authors confirm that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ASN EDI PB RB JP MA GC PJC. Performed the experiments: ASN EDI PB. Analyzed the data: ASN PB RB JP MA GC PJC. Contributed reagents/materials/analysis tools: ASN EDI PB MS. Wrote the paper: MS RB JP MA GC PJC.