About the Authors

Gergely Tóth

lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)

Affiliations Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, Elan Pharmaceuticals, South San Francisco, California, United States of America

Shyra J. Gardai

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Wagner Zago

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Carlos W. Bertoncini

Affiliations Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, SEDIPFAR (Servicio De Descubrimiento, Diseño Y Desarrollo Pre-Clínico De Fármacos De La Argentina) drug discovery platform, Universidad Nacional de Rosario, Rosario, Argentina

Nunilo Cremades

Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Susan L. Roy

Affiliation Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America

Mitali A. Tambe

Affiliation Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America

Jean-Christophe Rochet

Affiliation Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America

Celine Galvagnion

Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Gaia Skibinski

Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Taube-Koret Center for Neurodegenerative Disease Research, The Consortium for Frontotemporal Dementia Research, and The Hellman Family Foundation Program for Alzheimer’s Disease Research, San Francisco, California, United States of America

Steven Finkbeiner

Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Taube-Koret Center for Neurodegenerative Disease Research, The Consortium for Frontotemporal Dementia Research, and The Hellman Family Foundation Program for Alzheimer’s Disease Research, San Francisco, California, United States of America, Departments of Neurology and Physiology, UCSF, San Francisco, California, United States of America

Michael Bova

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Karin Regnstrom

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

San-San Chiou

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Jennifer Johnston

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Kari Callaway

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

John P. Anderson

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Michael F. Jobling

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Alexander K. Buell

Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Ted A. Yednock

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Tuomas P. J. Knowles

Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Michele Vendruscolo

lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)

Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

John Christodoulou

Affiliation Department of Structural & Molecular Biology, University College London, London, United Kingdom

Christopher M. Dobson

lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)

Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Dale Schenk

lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Lisa McConlogue

lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)

Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America

Competing Interests

We have read the journal's policy and have the following conflicts: some of the authors were employees and/or shareholders of Elan Pharmaceuticals as designated by Elan affiliation. Additional authors were supported in part by a grant from Elan Pharmaceuticals (CWB and NC). This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GT SG WZ CWB NC SLR MAT JR CG GS SF MB KR SC JJ KC JPA MFJ AKB TAY TPJK MV JC CMD DS LM. Performed the experiments: GT SG WZ CWB NC SLR MAT CG GS KR SC KC AKB. Analyzed the data: GT SG WZ CWB NC SLR MAT JR CG GS SF MB KR SC JJ KC JPA MFJ AKB TAY TPJK MV JC CMD DS LM. Contributed reagents/materials/analysis tools: GT SG WZ JR GS SF SC MV. Wrote the paper: GT SG WZ CWB NC JR GS KR MV CMD LM.