About the Authors
- Gergely Tóth
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* E-mail: lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)
Affiliations Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, Elan Pharmaceuticals, South San Francisco, California, United States of America
- Shyra J. Gardai
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Wagner Zago
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Carlos W. Bertoncini
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Affiliations Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, SEDIPFAR (Servicio De Descubrimiento, Diseño Y Desarrollo Pre-Clínico De Fármacos De La Argentina) drug discovery platform, Universidad Nacional de Rosario, Rosario, Argentina
- Nunilo Cremades
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Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
- Susan L. Roy
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Affiliation Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America
- Mitali A. Tambe
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Affiliation Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America
- Jean-Christophe Rochet
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Affiliation Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America
- Celine Galvagnion
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Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
- Gaia Skibinski
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Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Taube-Koret Center for Neurodegenerative Disease Research, The Consortium for Frontotemporal Dementia Research, and The Hellman Family Foundation Program for Alzheimer’s Disease Research, San Francisco, California, United States of America
- Steven Finkbeiner
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Affiliations Gladstone Institute of Neurological Disease, San Francisco, California, United States of America, Taube-Koret Center for Neurodegenerative Disease Research, The Consortium for Frontotemporal Dementia Research, and The Hellman Family Foundation Program for Alzheimer’s Disease Research, San Francisco, California, United States of America, Departments of Neurology and Physiology, UCSF, San Francisco, California, United States of America
- Michael Bova
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Karin Regnstrom
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- San-San Chiou
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Jennifer Johnston
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Kari Callaway
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- John P. Anderson
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Michael F. Jobling
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Alexander K. Buell
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Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
- Ted A. Yednock
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Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Tuomas P. J. Knowles
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Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
- Michele Vendruscolo
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* E-mail: lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)
Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
- John Christodoulou
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Affiliation Department of Structural & Molecular Biology, University College London, London, United Kingdom
- Christopher M. Dobson
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* E-mail: lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)
Affiliation Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
- Dale Schenk
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* E-mail: lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)
Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
- Lisa McConlogue
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* E-mail: lisam@msg.ucsf.edu (LM); gt293@cam.ac.uk (GT); mv245@cam.ac.uk (MV); dale.schenk@prothena.com (DS); cmd44@cam.ac.uk (CMD)
Affiliation Elan Pharmaceuticals, South San Francisco, California, United States of America
Competing Interests
We have read the journal's policy and have the following conflicts: some of the authors were employees and/or shareholders of Elan Pharmaceuticals as designated by Elan affiliation. Additional authors were supported in part by a grant from Elan Pharmaceuticals (CWB and NC). This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: GT SG WZ CWB NC SLR MAT JR CG GS SF MB KR SC JJ KC JPA MFJ AKB TAY TPJK MV JC CMD DS LM. Performed the experiments: GT SG WZ CWB NC SLR MAT CG GS KR SC KC AKB. Analyzed the data: GT SG WZ CWB NC SLR MAT JR CG GS SF MB KR SC JJ KC JPA MFJ AKB TAY TPJK MV JC CMD DS LM. Contributed reagents/materials/analysis tools: GT SG WZ JR GS SF SC MV. Wrote the paper: GT SG WZ CWB NC JR GS KR MV CMD LM.