About the Authors

Yen Ying Lim

y.lim@mhri.edu.au

Affiliation Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia

Victor L. Villemagne

Affiliations Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia, Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia

Simon M. Laws

Affiliations Centre of Excellence for Alzheimer’s Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia, Sir James McCusker Alzheimer’s Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia, Co-operative Research Centre for Mental Health, Carlton South, Australia

David Ames

Affiliations Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia, National Ageing Research Institute, Parkville, Victoria, Australia

Robert H. Pietrzak

Affiliation Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America

Kathryn A. Ellis

Affiliations Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia, Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia, National Ageing Research Institute, Parkville, Victoria, Australia

Karra Harrington

Affiliation Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia

Pierrick Bourgeat

Affiliation Commonwealth Scientific Industrial Research Organization Preventative Health National Research Flagship, Australian e-Health Research Centre-BioMedIA, Brisbane, Queensland, Australia

Ashley I. Bush

Affiliation Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia

Ralph N. Martins

Affiliations Centre of Excellence for Alzheimer’s Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia, Sir James McCusker Alzheimer’s Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia

Colin L. Masters

Affiliation Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia

Christopher C. Rowe

Affiliations Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia

Paul Maruff

Affiliations Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia, CogState Ltd., Melbourne, Victoria, Australia

for the AIBL Research Group

Competing Interests

YYL, SML, KE, RP, KH, PB, OS, CM and PM report no disclosures. VV serves as a consultant for Bayer Schering Pharma; and receives research support from NEDO, Japan. DA has served on scientific advisory boards for Novartis, Eli Lilly, Janssen, and Pfizer Inc.; has received funding for travel from Janssen and Pfizer Inc.; has received speaker honoraria from Pfizer Inc. and Lundbeck Inc.; and has received research support from Eli Lilly and Company, GlaxoSmithKline, Forest Laboratories Inc., and Novartis. AB is a paid consultant for Synthetic Biologics, and holds equity in Prana Biotechnology Ltd, CogState Ltd., and Eucalyptus Biosciences Pty Ltd. RM is a consultant to Alzhyme. CR serves on scientific advisory boards for Bayer Schering Pharma, Elan Corporation, and AstraZeneca; has received speaker honoraria from Bayer Schering Pharma; and receives research support from Bayer Schering Pharma, and Avid Radiopharmaceuticals, Inc. PM is a full-time employee of CogState Ltd. Simon Laws is supported by the Cooperative Research Centre for Mental Health, which is an Australian Response to Reviewers government initiative. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YYL PM SML. Performed the experiments: YYL KE VLV CR PB SML. Analyzed the data: YYL VLV SML PM. Contributed reagents/materials/analysis tools: DA RNM CLM PM KE VLV CR PB. Wrote the paper: YYL PM. Provided substantial revisions of manuscript for scientific content: SML DA KE CR VLV KH RNM RHP PB AIB CLM.