About the Authors

Becky R. Simon

Affiliation Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Brian S. Learman

Affiliation Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Sebastian D. Parlee

Affiliation Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Erica L. Scheller

Affiliation Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Hiroyuki Mori

Affiliation Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

William P. Cawthorn

Affiliations Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America, Musculoskeletal Research, Lilly Research Laboratories, Indianapolis, Indiana, United States of America

Xiaomin Ning

Affiliation Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America

Venkatesh Krishnan

Affiliation Musculoskeletal Research, Lilly Research Laboratories, Indianapolis, Indiana, United States of America

Yanfei L. Ma

Affiliation Musculoskeletal Research, Lilly Research Laboratories, Indianapolis, Indiana, United States of America

Björn Tyrberg

Affiliations Cardiovascular and Metabolic Disease, MedImmune LLC, Gaithersburg, Maryland, United States of America, Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, Florida, United States of America

Ormond A. MacDougald

macdouga@umich.edu

Affiliations Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

WPC is supported by a Lilly Innovation Fellowship Award. WPC, VK and YM are employed by Lilly Research Laboratories. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: BRS BSL SDP BT OAM. Performed the experiments: BRS BSL SDP ELS HM WPC XN VK YM BT. Analyzed the data: BRS SDP ELS VK YM. Contributed reagents/materials/analysis tools: BSL VK YM BT. Wrote the paper: BRS BSL SDP ELS HM WPC XN VK YM BT OAM.