About the Authors

Christina Avanti

Contributed equally to this work with: Christina Avanti, Vinay Saluja

Affiliations Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya (Ubaya), Surabaya, Indonesia, Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

Vinay Saluja

Contributed equally to this work with: Christina Avanti, Vinay Saluja

vinay.saluja@merck.com

Affiliations Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands, Pharmaceutical Sciences and Clinical Supply (PSCS), Development Center Oss, MSD, Oss, The Netherlands

Erwin L. P. van Streun

Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

Henderik W. Frijlink

Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

Wouter L. J. Hinrichs

Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

Competing Interests

The authors have the following interest. Vinay Saluja is affiliated to Pharmaceutical Sciences & Clinical Supply (PSCS), Development Center Oss, MSD. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: VS CA WLJH. Performed the experiments: VS CA ELPS. Analyzed the data: VS CA ELPS. Contributed reagents/materials/analysis tools: VS CA WLJH HWF. Wrote the paper: CA VS WLJH HWF.