About the Authors

Benjamin A. Samuels

Affiliation Departments of Psychiatry and Neuroscience, Columbia University, New York, New York, United States of America

E. David Leonardo

Affiliation Departments of Psychiatry and Neuroscience, Columbia University, New York, New York, United States of America

Alex Dranovsky

Affiliation Departments of Psychiatry and Neuroscience, Columbia University, New York, New York, United States of America

Amanda Williams

Affiliation AstraZeneca Pharmaceuticals, CNS Discovery, Wilmington, Delaware, United States of America

Erik Wong

Affiliation AstraZeneca Pharmaceuticals, CNS Discovery, Wilmington, Delaware, United States of America

Addie May I. Nesbitt

Affiliation Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Richard D. McCurdy

Affiliation Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Rene Hen

markalter1968@gmail.com (MA); rh95@columbia.edu (RH)

Affiliation Departments of Psychiatry and Neuroscience, Columbia University, New York, New York, United States of America

Mark Alter

markalter1968@gmail.com (MA); rh95@columbia.edu (RH)

Affiliation Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

Mark Alter is funded by 5K08MH080228-01 from NIMH. Benjamin Samuels is funded by 1K01MH098188-01 from NIMH. Amanda Williams and Erik Wong were full time employees of Astra Zeneca at the time of their participation in the study. Dr. Rene Hen receives compensation as a consultant for Lundbeck and Roche. Drs. Samuels, Leonardo, Dranovsky, Williams, Wong, McCurdy, and Alter have no potential conflicts to declare. Astra Zeneca paid for microarrays but was not involved in study design or data analysis. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BS EL AD RH MA. Performed the experiments: BS EL AD MA. Analyzed the data: MA. Contributed reagents/materials/analysis tools: AW EW. Wrote the paper: BS MA AN RM.