About the Authors

Nguyen Thi Ngoc Lan

Affiliation Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam

Nguyen Thi Nguyet Thu

Affiliation Pasteur Institute, Ho Chi Minh City, Vietnam

Aurélie Barrail-Tran

Affiliations Clinical Pharmacy Department, Bicêtre Hospital, Assistance-Publique Hôpitaux de Paris, Kremlin-Bicêtre, France, Clinical Pharmacy and Pharmacokinetics Department (EA4123), University Paris Sud, Chatenay Malabry, France

Nguyen Hong Duc

Affiliation Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam

Nguyen Ngoc Lan

Affiliation Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam

Didier Laureillard

Affiliation ANRS, Ho Chi Minh City, Vietnam

Truong Thi Xuan Lien

Affiliation Pasteur Institute, Ho Chi Minh City, Vietnam

Laurence Borand

Affiliation Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

Catherine Quillet

Affiliation ANRS, Ho Chi Minh City, Vietnam

Catherine Connolly

Affiliation Biostatistics Unit, Medical Research Council, Durban, South Africa

Dominique Lagarde

Affiliation The International Union Against Tuberculosis and Lung Diseases, Paris, France

Alexander Pym

Affiliations TB Research Unit, Medical Research Council, Durban, South Africa, KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), South Africa

Christian Lienhardt

Affiliation World Health Organization Stop Tuberculosis Program, Geneva, Switzerland

Nguyen Huy Dung

Affiliation Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam

Anne-Marie Taburet

Affiliation Clinical Pharmacy Department, Bicêtre Hospital, Assistance-Publique Hôpitaux de Paris, Kremlin-Bicêtre, France

Anthony D Harries

adharries@theunion.org

Affiliations The International Union Against Tuberculosis and Lung Diseases, Paris, France, London School of Hygiene and Tropical Medicine, London, United Kingdom

Competing Interests

The authors declare that the French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Institut national de la santé et de la recherche médicale-Agence Nationale de Recherche sur le Sida) was the Sponsor and Funder of the study. Fondation Total also provided a grant to support the study. The authors also declare that they received a donation of rifabutin from Laboratoires SERB and a donation of rifabutin and 25-O-desacetyl rifabutin reference powder from Pfizer (SA) which was used for the preparation of standard curves and quality control of assays. The French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (INSERM-ANRS), Fondation Total, Laboratoires SERB and Pfizer (SA) had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Furthermore, receipt of the donations from Laboratoires SERB and Pfizer (SA) does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NTNL D. Laureillard D. Lagarde AP CL ADH. Performed the experiments: NTNL NTNT ABT NHD NNL TTXL NHD. Analyzed the data: NTNT ABT AMT D. Laureillard LB CQ CC D. Lagarde. Wrote the paper: NTNL NTNT ABT NHD NNL D. Laureillard TTXL LB CQ CC D. Lagarde AP CL NHD AMT ADH. Wrote the first draft of the manuscript: AMT D. Lagarde ADH. ICMJE criteria for authorship read and met: NTNL NTNT ABT NHD NNL D. Laureillard TTXL LB CQ CC D. Lagarde AP CL NHD AMT ADH. Agree with manuscript results and conclusions: NTNL NTNT ABT NHD NNL D. Laureillard TTXL LB CQ CC D. Lagarde AP CL NHD AMT ADH.