Antagonistic Interplay between Necdin and Bmi1 Controls Proliferation of Neural Precursor Cells in the Embryonic Mouse Neocortex

Ryohei Minamide; Kazushiro Fujiwara; Koichi Hasegawa; Kazuaki Yoshikawa

doi:10.1371/journal.pone.0084460

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Open Access

Peer-reviewed

Research Article

Antagonistic Interplay between Necdin and Bmi1 Controls Proliferation of Neural Precursor Cells in the Embryonic Mouse Neocortex

Ryohei Minamide,

Affiliation Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
⨯
Kazushiro Fujiwara,

Affiliation Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
⨯
Koichi Hasegawa,

Affiliation Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
⨯
Kazuaki Yoshikawa

* E-mail: yoshikaw@protein.osaka-u.ac.jp

Affiliation Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
⨯

Antagonistic Interplay between Necdin and Bmi1 Controls Proliferation of Neural Precursor Cells in the Embryonic Mouse Neocortex

Ryohei Minamide,
Kazushiro Fujiwara,
Koichi Hasegawa,
Kazuaki Yoshikawa

Published: January 2, 2014
https://doi.org/10.1371/journal.pone.0084460

About the Authors

Ryohei Minamide

Affiliation Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, Japan

Kazushiro Fujiwara

Affiliation Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, Japan

Koichi Hasegawa

Affiliation Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, Japan

Kazuaki Yoshikawa

* E-mail: yoshikaw@protein.osaka-u.ac.jp

Affiliation Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RM KF KH KY. Performed the experiments: RM. Analyzed the data: RM KF KH KY. Contributed reagents/materials/analysis tools: KF KH KY. Wrote the paper: RM KY.

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Neocortex
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DNA-binding proteins
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Neurons
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Apoptosis
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Cell cycle and cell division
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Gene expression
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Viral gene expression
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Transfection
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