About the Authors

David Alexander Dickie

Affiliations Brain Research Imaging Centre (BRIC), The University of Edinburgh, Neuroimaging Sciences, Western General Hospital, Edinburgh, United Kingdom, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) collaboration, Edinburgh, United Kingdom

Dominic E. Job

Dominic.Job@ed.ac.uk

Affiliations Brain Research Imaging Centre (BRIC), The University of Edinburgh, Neuroimaging Sciences, Western General Hospital, Edinburgh, United Kingdom, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) collaboration, Edinburgh, United Kingdom

David Rodriguez Gonzalez

Affiliations Brain Research Imaging Centre (BRIC), The University of Edinburgh, Neuroimaging Sciences, Western General Hospital, Edinburgh, United Kingdom, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) collaboration, Edinburgh, United Kingdom

Susan D. Shenkin

Affiliations Geriatric Medicine Unit, The University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) collaboration, Edinburgh, United Kingdom

Trevor S. Ahearn

Affiliations Aberdeen Biomedical Imaging Centre, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) collaboration, Edinburgh, United Kingdom

Alison D. Murray

Affiliations Aberdeen Biomedical Imaging Centre, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) collaboration, Edinburgh, United Kingdom

Joanna M. Wardlaw

Affiliations Brain Research Imaging Centre (BRIC), The University of Edinburgh, Neuroimaging Sciences, Western General Hospital, Edinburgh, United Kingdom, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) collaboration, Edinburgh, United Kingdom

Competing Interests

Toshiba Medical Visualisation Systems Europe (TMVSE) provided support during David Alexander Dickie’s PhD training. This included provision of an industrial placement onsite with TMVSE and partial funding to support conference attendance. TMVSE did not fund the PhD stipend or fees, participate in analysis or writing of this submission and this relationship does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DAD DEJ JMW. Performed the experiments: DAD. Analyzed the data: DAD. Contributed reagents/materials/analysis tools: DAD. Wrote the manuscript: DAD DEJ DRG SDS TSA ADM JMW. Critically evaluated the method and analyses, and revised the manuscript: DEJ DRG SDS TSA ADM JMW.