Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells

Seyung S. Chung; Clement Aroh; Jaydutt V. Vadgama

doi:10.1371/journal.pone.0083971

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Open Access

Peer-reviewed

Research Article

Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells

Seyung S. Chung,

Affiliation Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California, United States of America
⨯
Clement Aroh,

Affiliation Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California, United States of America
⨯
Jaydutt V. Vadgama

* E-mail: jayvadgama@cdrewu.edu, jvadgama@ucla.edu

Affiliations Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, David Geffen UCLA School of Medicine, Los Angeles, California, United States of America
⨯

Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells

Seyung S. Chung,
Clement Aroh,
Jaydutt V. Vadgama

Published: December 30, 2013
https://doi.org/10.1371/journal.pone.0083971

About the Authors

Seyung S. Chung

Affiliation Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California, United States of America

Clement Aroh

Affiliation Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California, United States of America

Jaydutt V. Vadgama

* E-mail: jayvadgama@cdrewu.edu, jvadgama@ucla.edu

Affiliations Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, David Geffen UCLA School of Medicine, Los Angeles, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SSC JVV. Performed the experiments: SSC CR. Analyzed the data: SSC CR JVV. Contributed reagents/materials/analysis tools: SSC CR JVV. Wrote the paper: SSC JVV.

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Breast cancer
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Cancer stem cells
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STAT signaling
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Lung and intrathoracic tumors
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Gastric cancer
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Phosphorylation
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Stem cell therapy
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Metastasis
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