About the Authors

Suree Lekawanvijit

Affiliations Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Sirinart Kumfu

Affiliation Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Bing H. Wang

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia

Minako Manabe

Affiliation Pharmaceutical Department, Kureha Corporation, Tokyo, Japan

Fuyuhiko Nishijima

Affiliation Pharmaceutical Department, Kureha Corporation, Tokyo, Japan

Darren J. Kelly

Affiliation Department of Medicine, University of Melbourne, St. Vincent’s Hospital, Melbourne, Australia

Henry Krum

henry.krum@monash.edu

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia

Andrew R. Kompa

Affiliations Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, Department of Medicine, University of Melbourne, St. Vincent’s Hospital, Melbourne, Australia

Competing Interests

F.N. and M.M., employed by Kureha Corporation, were responsible for organizing the shipment of AST-120 (a gift from the company) and samples to measure IS levels (blind experiment). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SL DJK HK ARK. Performed the experiments: SL SK MM ARK. Analyzed the data: SL SK BHW ARK. Contributed reagents/materials/analysis tools: FN DJK HK. Wrote the manuscript: SL ARK. Edited and revised the manuscript: SL BHW HK ARK.