About the Authors

Niina Sokolova

Affiliation Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia

Shi Pan

Affiliation Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Sarah Provazza

Affiliation Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, United States of America

Gisela Beutner

Affiliation Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, United States of America

Marko Vendelin

Affiliation Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia

Rikke Birkedal

shey-shing.sheu@jefferson.edu (SSS); rikke@sysbio.ioc.ee (RB)

Affiliation Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia

Shey-Shing Sheu

shey-shing.sheu@jefferson.edu (SSS); rikke@sysbio.ioc.ee (RB)

Affiliations Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, United States of America, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SSS GB NS. Performed the experiments: NS S. Pan S. Provazza. Analyzed the data: NS MV RB. Contributed reagents/materials/analysis tools: SSS GB. Wrote the manuscript: RB NS S. Pan GB SSS. Prepared all the figures: NS.