About the Authors

Lori A. Coburn

Affiliations Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Sara N. Horst

Affiliations Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Rupesh Chaturvedi

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Caroline T. Brown

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Margaret M. Allaman

Affiliations Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Brooks P. Scull

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Kshipra Singh

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

M. Blanca Piazuelo

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Maithili V. Chitnavis

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Mallary E. Hodges

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Michael J. Rosen

Affiliation Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Christopher S. Williams

Affiliations Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

James C. Slaughter

Affiliation Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Dawn B. Beaulieu

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

David A. Schwartz

Affiliation Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Keith T. Wilson

keith.wilson@vanderbilt.edu

Affiliations Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Veterans Affairs Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: David A. Schwartz has consultancy agreements with Abbott, UCB, Janssen, Santarus, and Celgene and is currently receiving grants from Abbott and UCB. However, these agreements and grants had no relationship to the current research study. The authors are declaring that co-author Rupesh Chaturvedi is an academic editor for PLOS ONE. Also, since the original manuscript was submitted, Keith Wilson has entered into a consulting agreement with Immune Pharmaceuticals. However, he has not received any financial support of any kind from this company at this time. All of the authors' declarations do not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LAC DAS KTW. Performed the experiments: LAC SNH RC CTB MMA BPS KS MJR DBB MBP DAS. Analyzed the data: LAC RC MMA CSW JCS MVC MEH KTW. Contributed reagents/materials/analysis tools: MJR KS. Wrote the paper: LAC KTW. Obtained consent from patients: CTB.