About the Authors

Shohei Ogata

Affiliation Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, United States of America

Chisato Shimizu

Affiliation Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, United States of America

Alessandra Franco

Affiliation Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, United States of America

Ranim Touma

Affiliation Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, United States of America

John T. Kanegaye

Affiliations Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, United States of America, Rady Children’s Hospital San Diego, San Diego, California, United States of America

Biswa P. Choudhury

Affiliation Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of San Diego, School of Medicine, La Jolla, California, United States of America

Natasha N. Naidu

Affiliation Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of San Diego, School of Medicine, La Jolla, California, United States of America

Yutaka Kanda

Affiliation Kyowa Hakko Kirin California, Inc., La Jolla, California, United States of America

Long T. Hoang

Affiliation Division of Infectious Disease 1, Genome Institute of Singapore, Singapore, Singapore

Martin L. Hibberd

Affiliation Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore

Adriana H. Tremoulet

Affiliations Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, United States of America, Rady Children’s Hospital San Diego, San Diego, California, United States of America

Ajit Varki

Affiliation Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of San Diego, School of Medicine, La Jolla, California, United States of America

Jane C. Burns

jcburns@ucsd.edu

Affiliations Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, United States of America, Rady Children’s Hospital San Diego, San Diego, California, United States of America

Competing Interests

The authors hereby declare that co-author Dr. Yutaka Kanda is affiliated with Kyowa Hakko Kirin California, Inc., La Jolla, California, USA. The authors also confirm that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials, as detailed in the online guide for authors.

Author Contributions

Conceived and designed the experiments: JCB AV AHT. Performed the experiments: SO CS RT BPC NNN LTH. Analyzed the data: SO CS RT BPC NNN LTH. Contributed reagents/materials/analysis tools: SO JTK CS RT BPC NNN LTH. Wrote the manuscript: SO CS JTK JCB. Helped in the design of experiments and provided helpful discussion of the results: YK AF MLH.