About the Authors

David P. Hall

Affiliations Royal Air Force Centre of Aviation Medicine, RAF Henlow, Beds, United Kingdom, Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom

Ian J. C. MacCormick

Affiliation Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom

Alex T. Phythian-Adams

Affiliation Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom

Nina M. Rzechorzek

Affiliations Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom

David Hope-Jones

Affiliation Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom

Sorrel Cosens

Affiliation Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom

Stewart Jackson

Affiliation Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom

Matthew G. D. Bates

Affiliations Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

David J. Collier

Affiliation William Harvey Research Institute, Queen Mary University of London, London, United Kingdom

David A. Hume

Affiliation Division of Genetics and Genomics, Roslin Institute, Edinburgh, United Kingdom

Thomas Freeman

Affiliation Division of Genetics and Genomics, Roslin Institute, Edinburgh, United Kingdom

A. A. Roger Thompson

Affiliations Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom, Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, United Kingdom

John Kenneth Baillie

j.k.baillie@ed.ac.uk

Affiliations Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom, Division of Genetics and Genomics, Roslin Institute, Edinburgh, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JKB. Performed the experiments: DPH IJCM ATPA NMR DHJ SC SJ MGDB AART JKB. Analyzed the data: DPH JKB. Contributed reagents/materials/analysis tools: DJC DAH TF JKB. Wrote the paper: DPH AART JKB.