p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis

Benjamin J. Wilkins; Kristin Lorent; Randolph P. Matthews; Michael Pack

doi:10.1371/journal.pone.0077670

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Peer-reviewed

Research Article

p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis

Benjamin J. Wilkins,

Affiliation Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Kristin Lorent,

Affiliation Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Randolph P. Matthews,

Affiliation Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Michael Pack

* E-mail: mpack@mail.med.upenn.edu

Affiliation Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis

Benjamin J. Wilkins,
Kristin Lorent,
Randolph P. Matthews,
Michael Pack

Published: October 11, 2013
https://doi.org/10.1371/journal.pone.0077670

About the Authors

Benjamin J. Wilkins

Affiliation Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Kristin Lorent

Affiliation Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Randolph P. Matthews

Affiliation Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Michael Pack

* E-mail: mpack@mail.med.upenn.edu

Affiliation Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BJW RPM KL MP. Performed the experiments: BJW RPM KL. Analyzed the data: BJW RPM KL MP. Contributed reagents/materials/analysis tools: BJW RPM KL MP. Wrote the manuscript: BJW RPM KL MP.

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Larvae
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Zebrafish
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Hepatocytes
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Morpholino
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Ribosomal RNA
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Gene expression
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Gallbladder
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Ribosomes
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