About the Authors

Simon Wöhrle

Current address: Boehringer Ingelheim RCV GmbH & Co. KG., Vienna, Austria

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Andreas Weiss

Contributed equally to this work with: Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Moriko Ito

Contributed equally to this work with: Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Audrey Kauffmann

Contributed equally to this work with: Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Masato Murakami

Contributed equally to this work with: Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Zainab Jagani

Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

Anne Thuery

Current address: Centre for Immunology and Infection, Department of Biology, University of York, York, United Kingdom

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Beatrice Bauer-Probst

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Flavia Reimann

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Christelle Stamm

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Astrid Pornon

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Vincent Romanet

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Vito Guagnano

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Thomas Brümmendorf

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

William R. Sellers

Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

Francesco Hofmann

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Charles W. M. Roberts

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children’s Hospital Boston, Boston, Massachusetts, United States of America

Diana Graus Porta

diana.graus_porta@novartis.com

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Competing Interests

AW, MI, AK, MM, ZJ, BBP, FR, CS, AP, VG, T, WRS, FH and DGP are employees of Novartis Institutes for BioMedical Research. AT was an employee of Novartis Institutes for BioMedical Research. Author Simon Wöhrle was employed at Novartis Institutes for BioMedical Research during the whole course of this study. His present affiliation is with Boehringer Ingelheim as indicated in the Competing Interests section. The authors confirm that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SW WRS FH CWMR DGP. Performed the experiments: SW AT BBP FR CS AP VR. Analyzed the data: SW AW MI MM DGP AK VG TB. Contributed reagents/materials/analysis tools: AK TB ZJ CWMR. Wrote the paper: SW DGP.