Electrostatic Similarities between Protein and Small Molecule Ligands Facilitate the Design of Protein-Protein Interaction Inhibitors

Open Access

Peer-reviewed

Research Article

About the Authors

Arnout Voet

Contributed equally to this work with: Arnout Voet, Francois Berenger

Affiliation Zhang Initiative Research Unit, Institute Laboratories, RIKEN, Wako, Saitama, Japan

Francois Berenger

Contributed equally to this work with: Arnout Voet, Francois Berenger

Affiliation Zhang Initiative Research Unit, Institute Laboratories, RIKEN, Wako, Saitama, Japan

Kam Y. J. Zhang

* E-mail: kamzhang@riken.jp

Affiliation Zhang Initiative Research Unit, Institute Laboratories, RIKEN, Wako, Saitama, Japan

The authors have declared that no competing interests exist.

Conceived and designed the experiments: AV FB KYJZ. Performed the experiments: AV FB. Analyzed the data: AV FB KYJZ. Wrote the paper: AV FB KYJZ.

Electrostatics
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Small molecules
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Crystal structure
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Electrostatic bonding
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Protein structure
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Drug interactions
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Complement receptors
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Drug discovery
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