About the Authors

Kooresh I. Shoghi

shoghik@wustl.edu

Affiliations Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America

Jinbin Xu

Affiliation Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Yi Su

Affiliation Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

June He

Affiliation Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America

Douglas Rowland

Affiliation Center for Molecular and Genomic Imaging, University of California Davis, Davis, California, United States of America

Ying Yan

Affiliation Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America

Joel R. Garbow

Affiliation Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Zhude Tu

Affiliation Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Lynne A. Jones

Affiliation Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Ryuji Higashikubo

Affiliation Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America

Kenneth T. Wheeler

Affiliation Department of Radiology, Wake Forest University Health Science Center, Winston-Salem, North Carolina, United States of America

Ronald A. Lubet

Affiliation National Institutes of Health, Bethesda, Maryland, United States of America

Robert H. Mach

Affiliations Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America

Ming You

Affiliations Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America, Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Competing Interests

Drs. Robert Mach and Zhude Tu have a patent relating to the compound used in this work. The patent title is “Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging” (patent # US 7,659,400 B2) awarded February 9, 2010. Isotrace Technologies, LLC, St. Charles, Missouri, has a licensing agreement with Washington University School of Medicine for the commercialization of 18F-labeled sigma-2 receptor radiotracers developed in the laboratory of Dr. R.H. Mach. Dr. Mach and Dr. Tu have no financial interests in Isotrace Technologies, nor are they paid consultants for the company. The patent does not alter the authors’ adherence to the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KIS JX JH DR JRG LAJ RAL KTW RHM MY. Performed the experiments: JX JH DR YY RH LAJ. Analyzed the data: KIS JX YS JH DR YY LAJ. Contributed reagents/materials/analysis tools: ZT. Wrote the paper: KIS JX JRG LAJ RHM MY.