About the Authors

Summer L. Gibbs

gibbss@ohsu.edu

Current address: Department of Biomedical Engineering, Knight Cancer Institute and Center for Spatial Systems Biomedicine, Oregon Health and Science University, Portland, Oregon, United States of America

Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Yang Xie

Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Haley L. Goodwill

Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Khaled A. Nasr

Affiliation Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Yoshitomo Ashitate

Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Victoria J. Madigan

Affiliation Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Tiberiu M. Siclovan

Affiliation Diagnostics and Biomedical Technologies, GE Global Research, Niskayuna, New York, United States of America

Maria Zavodszky

Affiliation Diagnostics and Biomedical Technologies, GE Global Research, Niskayuna, New York, United States of America

Cristina A. Tan Hehir

Affiliation Diagnostics and Biomedical Technologies, GE Global Research, Niskayuna, New York, United States of America

John V. Frangioni

Affiliations Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared the following interests: FLARETM technology is owned by Beth Israel Deaconess Medical Center, a teaching hospital of Harvard Medical School. It has been licensed to the FLARETM Foundation, a non-profit organization focused on promoting the dissemination of medical imaging technology for research and clinical use. Dr. Frangioni is the founder and chairman of the FLARETM Foundation. The Beth Israel Deaconess Medical Center will receive royalties for sale of FLARETM Technology. Dr. Frangioni has elected to surrender post-market royalties to which he would otherwise be entitled as inventor, and has elected to donate pre-market proceeds to the FLARETM Foundation. Dr. Frangioni has started three for-profit companies, Curadel, Curadel ResVet Imaging, and Curadel Surgical Innovations, which may someday be non-exclusive sub-licensees of FLARETM technology. Co-authors Tiberiu M. Siclovan, Maria Zavodszky and Cristina A. Tan Hehir are employed by General Electric Company. Drs. Siclovan and Tan Hehir are inventors of patents and patent applications on technologies related to nerve imaging. These include US8169696B2 (Systems for intraoperative nerve imaging); US8114382B2 (Myelin detection using benzofuran derivatives); US20110142759A1 (Agents and methods for the imaging of myelin basic protein); US20100310457A1 and US20100310456A1 (imaging of myelin basic protein). There are no further products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SLG KAN YA JVF. Performed the experiments: SLG YX HLG KAN YA VJM MZ. Analyzed the data: SLG YX HLG KAN YA VJM TMS MZ. Contributed reagents/materials/analysis tools: SLG YX HLG VJM TMS MZ CAT. Wrote the manuscript: SLG.