Hyperoxia Decreases Glycolytic Capacity, Glycolytic Reserve and Oxidative Phosphorylation in MLE-12 Cells and Inhibits Complex I and II Function, but Not Complex IV in Isolated Mouse Lung Mitochondria

Kumuda C. Das

doi:10.1371/journal.pone.0073358

Loading metrics

Open Access

Peer-reviewed

Research Article

Hyperoxia Decreases Glycolytic Capacity, Glycolytic Reserve and Oxidative Phosphorylation in MLE-12 Cells and Inhibits Complex I and II Function, but Not Complex IV in Isolated Mouse Lung Mitochondria

Kumuda C. Das

* E-mail: kumuda.das@ttuhsc.edu

Affiliation Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America
⨯

Hyperoxia Decreases Glycolytic Capacity, Glycolytic Reserve and Oxidative Phosphorylation in MLE-12 Cells and Inhibits Complex I and II Function, but Not Complex IV in Isolated Mouse Lung Mitochondria

Kumuda C. Das

Published: September 2, 2013
https://doi.org/10.1371/journal.pone.0073358

About the Authors

Kumuda C. Das

* E-mail: kumuda.das@ttuhsc.edu

Affiliation Department of Anesthesiology, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

Competing Interests

The author has declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KD. Conceived and designed the experiments: KD. Performed the experiments: KD. Performed the experiments: KD. Analyzed the data: KD. Analyzed the data: KD. Wrote the paper: KD. Wrote the paper: KD.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hyperoxia
Is the Subject Area "Hyperoxia" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Respiratory physiology
Is the Subject Area "Respiratory physiology" applicable to this article?

Thanks for your feedback.
Glycolysis
Is the Subject Area "Glycolysis" applicable to this article?

Thanks for your feedback.
Oxygen
Is the Subject Area "Oxygen" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Bioenergetics
Is the Subject Area "Bioenergetics" applicable to this article?

Thanks for your feedback.
Pyruvate
Is the Subject Area "Pyruvate" applicable to this article?

Thanks for your feedback.