About the Authors

Timo Frensing

Contributed equally to this work with: Timo Frensing, Frank Stefan Heldt

frensing@mpi-magdeburg.mpg.de

Affiliation Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Frank Stefan Heldt

Contributed equally to this work with: Timo Frensing, Frank Stefan Heldt

Affiliation Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Antje Pflugmacher

Affiliation Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Ilona Behrendt

Affiliation Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Ingo Jordan

Affiliation ProBioGen AG, Berlin, Germany

Dietrich Flockerzi

Affiliation Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Yvonne Genzel

Affiliation Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Udo Reichl

Affiliations Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany, Chair for Bioprocess Engineering, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany

Competing Interests

The authors have the following interests. Ingo Jordan is employed by ProBioGen AG. IJ has applied for patents on the Muscovy duck cell line and its use in production of viruses. Patent application numbers: WO 2005/042728 and WO 2007/054516. There are no further patents, products in development or marketed products to declare. This does not alter the authors′ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: TF FSH YG UR. Performed the experiments: AP IB. Analyzed the data: TF FSH DF YG UR. Contributed reagents/materials/analysis tools: IJ. Wrote the paper: TF FSH IJ DF UR.