About the Authors

Benjamin Rix Brooks

Affiliation Carolinas Medical Center, University of North Carolina School of Medicine–Charlotte Campus, Charlotte, North Carolina, United States of America

David Crumpacker

Affiliation Baylor University Medical Center, Dallas, Texas, United States of America

Jonathan Fellus

Affiliation International Brain Research Foundation, Flanders, New Jersey, United States of America

Daniel Kantor

Affiliation Neurologique, Ponte Vedra Beach, Florida, United States of America

Randall E. Kaye


Affiliation Avanir Pharmaceuticals, Inc., Aliso Viejo, California, United States of America

Competing Interests

Funding for the PRISM study and editorial support for manuscript preparation were provided by Avanir Pharmaceuticals, Inc. Other potential conflicts of interest are as follows: Dr. Brooks has received funding and/or research grants from Biogen Idec, Avanir Pharmaceuticals, Inc., Acorda, Cytokinetics, GlaxoSmithKline Pharmaceuticals, Neuraltus Pharmaceuticals, NINDS Clinical Research Consortium, Synapse; Dr. Crumpacker has served on a scientific advisory board for and received speaking fees from Avanir Pharmaceuticals, Inc., and has received speaking fees from Accera and Novartis; Dr. Fellus has received a research grant and consulting fees from, has served on the Speakers Bureau for, and is a stockholder of Avanir Pharmaceuticals, Inc.; Dr. Kantor has received consulting fees from Avanir Pharmaceuticals, Inc.; Dr. Kaye is an employee and stockholder of Avanir Pharmaceuticals, Inc. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RK JF. Analyzed the data: BB DC JF DK RK. Wrote the paper: BB DC JF DK RK. Investigators in the study: DC DK BB.