About the Authors

Fei Wu

Affiliation Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, United States of America

Lili Guo

Affiliation Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Aniela Jakubowski

Affiliation Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, United States of America

Lihe Su

Current address: AB Biosciences, Allston, Massachusetts, United States of America

Affiliation Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, United States of America

Wan-Chun Li

Current address: Department of Dentistry and Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan

Affiliation Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Susan Bonner-Weir

Contributed equally to this work with: Susan Bonner-Weir, Linda C. Burkly

Affiliation Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Linda C. Burkly

Contributed equally to this work with: Susan Bonner-Weir, Linda C. Burkly

linda.burkly@biogenidec.com

Affiliation Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, United States of America

Competing Interests

F.W., A.J. and L.S. are former employees of Biogen Idec, and L.C.B. is currently an employee and stockholder in Biogen Idec. This does not alter the authors' adherence to all of the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FW SB LCB. Performed the experiments: FW LG WL AJ. Analyzed the data: FW LG WL AJ. Contributed reagents/materials/analysis tools: LS. Wrote the paper: FW SB LCB.