About the Authors

Shih-Wei Lin

Contributed equally to this work with: Shih-Wei Lin, Yen-Lung Chen

Affiliation Sleep Center, Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Tayuan, Taiwan

Yen-Lung Chen

Contributed equally to this work with: Shih-Wei Lin, Yen-Lung Chen

Affiliations Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Graduate Institute of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan

Kuo-Chin Kao

Affiliations Department of Thoracic Medicine and Respiratory Therapy, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Department of Respiratory Therapy, Chang Gung University, Taoyuan, Taiwan

Cheng-Ta Yang

Affiliations Department of Thoracic Medicine and Respiratory Therapy, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Department of Respiratory Therapy, Chang Gung University, Taoyuan, Taiwan

Li-Pang Chuang

Affiliations Sleep Center, Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Tayuan, Taiwan, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan

Yu-Ting Chou

Affiliations Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan, Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan

Szu-Chia Lai

Affiliation Sleep Center, Movement Disorder Section, Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Rou-Shayn Chen

Affiliation Sleep Center, Movement Disorder Section, Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Ning-Hung Chen

ninghung@yahoo.com.tw, nhchen@cgmh.org.tw

Affiliation Sleep Center, Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Tayuan, Taiwan

Competing Interests

This study is partly sponsored by GlaxoSmithKline (XMRPG380121). The GlaxoSmithKline Company sponsored manpower of a research assistant for 6 months which cost around 8,000 USD. However, they have no role in study design and conduct, collection, analysis, and interpretation of the data, or writing or approval of the manuscript. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: N-HC S-CL. Performed the experiments: S-WL Y-LC K-CK C-TY L-PC Y-TC S-CL R-SC N-HC. Analyzed the data: S-WL Y-LC. Contributed reagents/materials/analysis tools: N-HC. Wrote the paper: S-WL Y-LC.