About the Authors

Vinicius Bassaneze

Affiliation Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, São Paulo, Brazil

Chester Bittencourt Sacramento

Affiliation Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, São Paulo, Brazil

Rodolfo Freire

Affiliation Center of Fuzzy Systems in Health, Faculty of Medicine, University of São Paulo, Department of Pathology, São Paulo, São Paulo, Brazil

Patrícia Fernandes De Alencar

Affiliation Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, São Paulo, Brazil

Neli Regina Siqueira Ortega

Affiliation Center of Fuzzy Systems in Health, Faculty of Medicine, University of São Paulo, Department of Pathology, São Paulo, São Paulo, Brazil

Jose Eduardo Krieger

krieger@incor.usp.br

Affiliation Laboratory of Genetics and Molecular Cardiology/LIM 13, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, São Paulo, Brazil

Competing Interests

The authors have read the journal's policy and have the following conflicts: Funding for this study was received from Roche Pharmaceutical. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: VB CBS RF NRSO JEK. Performed the experiments: VB CBS PFDA. Analyzed the data: VB CBS RF NRSO. Contributed reagents/materials/analysis tools: NRSO JEK. Wrote the paper: VB NRSO JEK.