About the Authors

Mariana Lopes dos Santos

Affiliations Lab. de Biofármacos em Células Animais, Instituto Butantan, São Paulo, Brazil, Recepta Biopharma, São Paulo, Brazil

Fernanda Perez Yeda

Affiliations Lab. de Biofármacos em Células Animais, Instituto Butantan, São Paulo, Brazil, Recepta Biopharma, São Paulo, Brazil

Lilian Rumi Tsuruta

Affiliations Lab. de Biofármacos em Células Animais, Instituto Butantan, São Paulo, Brazil, Recepta Biopharma, São Paulo, Brazil

Bruno Brasil Horta

Current address: U.S. Pharmacopeial Convention, São Paulo, Brasil

Affiliations Lab. de Biofármacos em Células Animais, Instituto Butantan, São Paulo, Brazil, Recepta Biopharma, São Paulo, Brazil

Alécio A. Pimenta Jr

Current address: GE Life Sciences, São Paulo branch, SP, Brazil

Affiliations Lab. de Biofármacos em Células Animais, Instituto Butantan, São Paulo, Brazil, Recepta Biopharma, São Paulo, Brazil

Theri Leica Degaki

Current address: Instituto de Química, Universidade de São Paulo, SP, Brazil

Affiliations Lab. de Biofármacos em Células Animais, Instituto Butantan, São Paulo, Brazil, Recepta Biopharma, São Paulo, Brazil

Ibere C. Soares

Affiliations Recepta Biopharma, São Paulo, Brazil, LIM14-Depto. de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

Maria Carolina Tuma

Affiliation Recepta Biopharma, São Paulo, Brazil

Oswaldo Keith Okamoto

Affiliations Recepta Biopharma, São Paulo, Brazil, Depto. de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil

Venancio A. F. Alves

Affiliations Recepta Biopharma, São Paulo, Brazil, LIM14-Depto. de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

Lloyd J. Old

† Deceased.

Affiliation Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, United States of America

Gerd Ritter

Affiliation Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, United States of America

Ana Maria Moro

anamoro@butantan.gov.br

Affiliation Lab. de Biofármacos em Células Animais, Instituto Butantan, São Paulo, Brazil

Competing Interests

MLS, FPY, LRT, BBH, AAPJr, TLD, ICS received fellowships from Recepta biopharma during the realization of this work. The grants were provided by Recepta biopharma through Government funding. MCT is employed by Recepta biopharma. VAFA and OKO acted as consultants for Recepta biopharma. AMM received a fellowship through Fundação Butantan. GR is listed as an inventor on a patent application (PCT/US200900576) on the “Membrane Transporter NaPi2b (SLC34A2)Epitope for Antibody Therapy, Antibodies directed thereto and Target for Cancer Therapy”. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AMM. Performed the experiments: MLS FPY LRT BBH AAP TLD ICS. Analyzed the data: AMM LRT BBH VAFA GR. Contributed reagents/materials/analysis tools: LJO OKO MCT. Wrote the paper: AMM MLS. Critical review of the manuscript: GR MCT OKO. Coordination of the study and funding: AMM.