About the Authors

Sungeun Kim

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Shanker Swaminathan

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Mark Inlow

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Mathematics, Rose-Hulman Institute of Technology, Terre Haute, Indiana, United States of America

Shannon L. Risacher

Affiliation Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Kwangsik Nho

Affiliation Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Li Shen

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Tatiana M. Foroud

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Ronald C. Petersen

Affiliation Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

Paul S. Aisen

Affiliation Department of Neurology, University of California San Diego, San Diego, California, United States of America

Holly Soares

Affiliation Bristol Myers Squibb Co, Wallingford, Connecticut, United States of America

Jon B. Toledo

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Leslie M. Shaw

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

John Q. Trojanowski

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Michael W. Weiner

Affiliations Departments of Radiology, Medicine and Psychiatry, University of California, San Francisco, San Francisco, California, United States of America, Department of Veterans Affairs Medical Center, San Francisco, California, United States of America

Brenna C. McDonald

Affiliation Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Martin R. Farlow

Affiliation Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Bernardino Ghetti

Affiliation Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Andrew J. Saykin

asaykin@iupui.edu

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Competing Interests

ADNI is funded in part through generous contributions from the following: Abbott; Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; Amorfix Life Sciences Ltd.; AstraZeneca; Bayer HealthCare; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. However, no funding from any commercial source, listed in the paper, was directly received by the authors. Co-author Holly Soares is employed by Bristol Myers Squibb Co. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SK AJS MI. Performed the experiments: SK MI SS SLR KN LS. Analyzed the data: SK SS MI AJS. Contributed reagents/materials/analysis tools: SLR KN TF RCP PSA HS JBT LMS JQT MWW BCM MRF BG. Wrote the paper: SK SS MI SLR JQT AJS.