About the Authors

Mitko Veta

mitko@isi.uu.nl

Affiliation Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands

Paul J. van Diest

Affiliation Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

Robert Kornegoor

Affiliation Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

André Huisman

Affiliation Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

Max A. Viergever

Affiliation Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands

Josien P. W. Pluim

Affiliation Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MV PJvD AH MAV JPWP. Performed the experiments: MV. Analyzed the data: MV PJvD JPWP. Wrote the manuscript: MV AH MAV JPWP. Selected cases for the training set and graded them for nuclear pleomorphism: PJvD. Performed manual nuclei segmentation: RK. Retrieved and scanned the histological slides: AH. Made suggestions and revisions of the manuscript and approved it for publication: MV PJvD RK AH MAV JPWP.