About the Authors

Sanchita Roy

Affiliations Department of Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, United States of America, Department of Internal Medicine, Wayne State University, Detroit, Michigan, United States of America

Yingjie Yu

Affiliations Department of Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, United States of America, Department of Internal Medicine, Wayne State University, Detroit, Michigan, United States of America

Subhash B. Padhye

Affiliation ISTRA, Department of Chemistry, MCE Society′s Abeda Inamdar Senior College of Arts, Science and Commerce, Pune, India

Fazlul H. Sarkar

Affiliations Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America, Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America

Adhip P.N. Majumdar

a.majumdar@wayne.edu

Affiliations Department of Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, United States of America, Department of Internal Medicine, Wayne State University, Detroit, Michigan, United States of America, Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: APNM FHS. Performed the experiments: SR APNM FHS. Analyzed the data: SR APNM FHS. Wrote the paper: SR APNM FHS. Designed and synthesized CDF: SBP. Generated FU-Ox resistant (chemo-resistant; CR) HCT116, HT29 cells also miR-21 expressing colon cell line: YY. Generated SCID xenografts of, miR-21-overexpressing HCT116 cells and the corresponding pCMV-transfected control cells: YY.