About the Authors

Xi Lu

Contributed equally to this work with: Xi Lu, Xinyi Yang

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Xinyi Yang

Contributed equally to this work with: Xi Lu, Xinyi Yang

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Xue Li

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Yun Lu

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Zhitao Ren

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Longyin Zhao

Affiliations Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Beijing Standard Herbs Medical Science and Technology Development Co. LTD., Beijing, China

Xinxin Hu

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Jiandong Jiang

xuefuyou@imb.pumc.edu.cn (X. You); jiang.jdong@163.com (JJ)

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Xuefu You

xuefuyou@imb.pumc.edu.cn (X. You); jiang.jdong@163.com (JJ)

Affiliation Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Competing Interests

LZ holds equity interest in Beijing Standard Herbs Medical Science & Technology Development Co. LTD. The company will provide sodium houttuyfonate upon request. The company didn’t participated in the design or execution of this study or writing the manuscript. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. There are no other relevant declarations relating to employment, consultancy, patents, products in development or marketed products.

Author Contributions

Conceived and designed the experiments: X. You JJ X. Lu X. Yang. Performed the experiments: X. Lu X. Yang X. Li YL ZR XH. Analyzed the data: X. Yang X. Lu X. You. Contributed reagents/materials/analysis tools: LZ. Wrote the paper: X. Lu X. Yang.