About the Authors

Maria Takacs

Affiliation Department of Integrative Structural Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Centre National de la Recherche Scientifique (CNRS), UMR 7104, Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Université de Strasbourg (UdS), Illkirch, France

Maxim V. Petoukhov

Affiliation European Molecular Biology Laboratory, Hamburg Outstation, EMBL DESY, Hamburg, Germany

R. Andrew Atkinson

Affiliation Centre for Biomolecular Spectroscopy and Randall Division of Cell and Molecular Biophysics, King’s College London, London, United Kingdom

Pierre Roblin

Affiliations SOLEIL Synchrotron, L'Orme des Merisiers Saint-Aubin, Gif-sur-Yvette, France, INRA-URBIA, Nantes, France

François-Xavier Ogi

Affiliation NanoTemper Technologies GmbH, Munich, Germany

Borries Demeler

Affiliation Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas, United States of America

Noelle Potier

Affiliation Institut de Chimie LC3, Université de Strasbourg, Centre National de la Recherche Scientifique (CNRS), UMR 7177, Strasbourg, France

Yassmine Chebaro

Affiliation Department of Integrative Structural Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Centre National de la Recherche Scientifique (CNRS), UMR 7104, Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Université de Strasbourg (UdS), Illkirch, France

Annick Dejaegere

Affiliation Department of Integrative Structural Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Centre National de la Recherche Scientifique (CNRS), UMR 7104, Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Université de Strasbourg (UdS), Illkirch, France

Dmitri I. Svergun

Affiliation European Molecular Biology Laboratory, Hamburg Outstation, EMBL DESY, Hamburg, Germany

Dino Moras

Affiliation Department of Integrative Structural Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Centre National de la Recherche Scientifique (CNRS), UMR 7104, Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Université de Strasbourg (UdS), Illkirch, France

Isabelle M. L. Billas

billas@igbmc.fr

Affiliation Department of Integrative Structural Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Centre National de la Recherche Scientifique (CNRS), UMR 7104, Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Université de Strasbourg (UdS), Illkirch, France

Competing Interests

FXO is employed by Nanotemper Technologies GmbH. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and material.

Author Contributions

Conceived and designed the experiments: DM IMLB MT RAA. Performed the experiments: FXO IMLB MT NP PR RAA. Analyzed the data: AD BD DM DIS FXO IMLB MVP MT NP PR RAA YC. Contributed reagents/materials/analysis tools: AD FXO IMLB MVP MT NP PR RAA. Wrote the paper: DM IMLB MT MVP PR RAA.