About the Authors

Susan Kühnast

Contributed equally to this work with: Susan Kühnast, Mieke C. Louwe

susan.jordaan@tno.nl

Affiliations TNO - Metabolic Health Research, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Mieke C. Louwe

Contributed equally to this work with: Susan Kühnast, Mieke C. Louwe

Affiliations Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Mattijs M. Heemskerk

Affiliations Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Elsbet J. Pieterman

Affiliation TNO - Metabolic Health Research, Leiden, The Netherlands

Jan B. van Klinken

Affiliations Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Sjoerd A. A. van den Berg

Affiliations Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Johannes W. A. Smit

Affiliations Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Louis M. Havekes

Affiliations TNO - Metabolic Health Research, Leiden, The Netherlands, Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Patrick C. N. Rensen

Affiliations Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

José W. A. van der Hoorn

Affiliations TNO - Metabolic Health Research, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Hans M. G. Princen

These authors also contributed equally to this work.

Affiliation TNO - Metabolic Health Research, Leiden, The Netherlands

J. Wouter Jukema

These authors also contributed equally to this work.

Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

Competing Interests

JWJ received research grants from and was speaker on (CME accredited) meetings sponsored by Astellas, Astra-Zeneca, Biotronik, Boston Scientific, Daiichi Sankyo, Lilly, Genzyme, Medtronic, Merck-Schering-Plough, Pfizer, Orbus Neich, Novartis, Roche, Servier, Sanofi Aventis, the Netherlands Heart Foundation, the Interuniversity Cardiology Institute of the Netherlands and the European Community Framework KP7 Programme. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PCNR JWAvdH HMGP JWJ. Performed the experiments: SK MCL MMH EJP SAAvdB JWAvdH. Analyzed the data: SK MCL MMH EJP JBvK SAAvdB JWAvdH. Wrote the paper: SK MCL JBvK JWAS LMH JWAvdH PCNR HMGP JWJ.