About the Authors

Jie Xu

Contributed equally to this work with: Jie Xu, Xingquan Zhao

Affiliation Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Xingquan Zhao

Contributed equally to this work with: Jie Xu, Xingquan Zhao

Affiliation Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Yilong Wang

Affiliation Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Chunxue Wang

Affiliation Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Liping Liu

Affiliation Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Baoying Sun

Affiliation Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China

Anxin Wang

Affiliation Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Yongjun Wang

yongjunwang1962@gmail.com

Affiliation Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Competing Interests

This study was supported in part by Beijing Novartis Pharma Co., Ltd. Beijing Novartis Pharma Co., Ltd. markets antihypertension drugs. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: Yongjun Wang. Performed the experiments: Yilong Wang CW LL. Analyzed the data: JX XZ. Wrote the paper: JX XZ. Statistical analysis: BS AW.