About the Authors

Helge Ræder

helge.rader@uib.no

Affiliations Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, KG Jebsen Center for Diabetes Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Department of Pediatrics, Haukeland University Hospital, Bergen, Norway, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway

Mette Vesterhus

Affiliations Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, KG Jebsen Center for Diabetes Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Department of Pediatrics, Haukeland University Hospital, Bergen, Norway

Abdelfattah El Ouaamari

Affiliation Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America

Joao A. Paulo

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Fiona E. McAllister

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Chong Wee Liew

Affiliation Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America

Jiang Hu

Affiliation Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America

Dan Kawamori

Affiliation Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America

Anders Molven

Affiliations Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, KG Jebsen Center for Diabetes Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway, The Gade Institute, University of Bergen, Bergen, Norway, Department of Pathology, Haukeland University Hospital, Bergen, Norway

Steven P. Gygi

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Pål R. Njølstad

Affiliations Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, KG Jebsen Center for Diabetes Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Department of Pediatrics, Haukeland University Hospital, Bergen, Norway, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

C. Ronald Kahn

Affiliation Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America

Rohit N. Kulkarni

Affiliation Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors declare the commercial funder Innovest: Innovest is a company that is owned by the University of Bergen and Haukeland University Hospital, both in Bergen, Norway. Innovest is managing funds and grants for researchers employed by the two institutions. Innovest also manages some strategic funds from the two institutions, and PRN receives 100000 US$ yearly from these. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HR MV PRN CRK RNK. Performed the experiments: HR MV AEO JAP FEM JH DK PRN. Analyzed the data: HR MV AEO JAP FEM CWL JH DK AM SPG PRN CRK RNK. Wrote the paper: HR MV AEO JAP FEM CWL JH DK AM SPG PRN CRK RNK.