About the Authors

Barbara Klink

Contributed equally to this work with: Barbara Klink, Hrvoje Miletic, Daniel Stieber, Peter C. Huszthy

Affiliation Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Hrvoje Miletic

Contributed equally to this work with: Barbara Klink, Hrvoje Miletic, Daniel Stieber, Peter C. Huszthy

Affiliations Department of Biomedicine, University of Bergen, Bergen, Norway, The Gade Institute, Department of Pathology, Haukeland University Hospital, Bergen, Norway

Daniel Stieber

Contributed equally to this work with: Barbara Klink, Hrvoje Miletic, Daniel Stieber, Peter C. Huszthy

Affiliation Centre de Recherche Public de la Santé, Luxembourg

Peter C. Huszthy

Contributed equally to this work with: Barbara Klink, Hrvoje Miletic, Daniel Stieber, Peter C. Huszthy

Affiliations Department of Biomedicine, University of Bergen, Bergen, Norway, Department for Histology and Embryology, School of Medicine, University of Rijeka, Rijeka, Croatia

Jaime Alberto Campos Valenzuela

Affiliation Institut für Medizinische Informatik und Biometrie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Jörg Balss

Affiliation Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Jian Wang

Affiliations Department of Biomedicine, University of Bergen, Bergen, Norway, Oncomatrix Research Laboratory, Department of Biomedicine, University of Bergen, Jonas Bergen, Norway

Manja Schubert

Affiliation Department of Clinical Medicine, Section Neurology, Haukeland University Hospital, Bergen, Norway

Per Øystein Sakariassen

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Terje Sundstrøm

Affiliations Department of Biomedicine, University of Bergen, Bergen, Norway, Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway, Department of Surgical Sciences, University of Bergen, Bergen, Norway

Anja Torsvik

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Mads Aarhus

Affiliation Department of Neurosurgery, Oslo University Hospital, Oslo, Norway

Rupavathana Mahesparan

Affiliation Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway

Andreas von Deimling

Affiliations Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany

Lars Kaderali

Affiliation Institut für Medizinische Informatik und Biometrie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Simone P. Niclou

Affiliation Centre de Recherche Public de la Santé, Luxembourg

Evelin Schröck

Affiliation Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Rolf Bjerkvig

Affiliations Department of Biomedicine, University of Bergen, Bergen, Norway, Centre de Recherche Public de la Santé, Luxembourg

Janice M. Nigro

janice.nigro@biomed.uib.no

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway

Competing Interests

The authors have read the journal's policy and have the following conflicts: Jörg Balss and Andreas von Deimling applied for a patent on the biochemical assay for 2-hydroxyglutarate detection. All terms are being managed by the German Cancer Cover Letter Research Center in accordance with its conflict of interest policies. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Number EP 12 157 663.1 is the number for the European patent application submitted 01 March, 2012 and entitled “Means and Methods for the Determination of (D)-2-Hydroxyglutarate (D2HG).”

Author Contributions

Conceived and designed the experiments: JMN. Performed the experiments: JMN BK HM DS PCH JACV JB JW MS TS AT. Analyzed the data: JMN BK HM DS PCH JACV JB JW TS AT AvD SPN LK ES. Contributed reagents/materials/analysis tools: PØS MA RM. Wrote the paper: JMN RB BK.