About the Authors

Akiko Niibori-Nambu

Contributed equally to this work with: Akiko Niibori-Nambu, Uichi Midorikawa

Affiliation Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Uichi Midorikawa

Contributed equally to this work with: Akiko Niibori-Nambu, Uichi Midorikawa

Affiliations Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan, Healthcare Systems Laboratories, Sharp Corp. Chiba-city, Japan

Souhei Mizuguchi

Affiliation Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Takuichiro Hide

Affiliation Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Minako Nagai

Affiliation Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Yoshihiro Komohara

Affiliation Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Megumi Nagayama

Affiliation Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Mio Hirayama

Affiliation Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Daiki Kobayashi

Affiliation Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Nobuyuki Tsubota

Affiliations Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan, Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Tatsuya Takezaki

Affiliation Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Keishi Makino

Affiliation Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Hideo Nakamura

Affiliation Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Motohiro Takeya

Affiliation Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Junichi Kuratsu

Affiliation Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Norie Araki

nori@gpo.kumamoto-u.ac.jp

Affiliation Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto-city, Japan

Competing Interests

One of the first authors, Uichi Midorikawa, is a Ph.D. student of Graduate School of Medicine, Kumamoto University, entering from the workforce of The Healthcare Systems Laboratories, Sharp Corp. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NA. Performed the experiments: ANN UM MN YK MN SM MH DK. Analyzed the data: SM ANN UM DK NA. Contributed reagents/materials/analysis tools: TH NT TT KM HN MT JK. Wrote the paper: ANN UM NA. Designed the programming iPEACH used in analysis: SM NA. Obtained permission for use of glioma tissue: NT TT HN TH JK. Performed mouse xenograft used in experiment: ANN UM Minako Nagai TT NA. Established GIC cell lines used in experiment: ANN UM Minako Nagai NT TH NA. Performed Pathological analysis of mouse xenograft tissues: YM MT ANN Minako Nagai NA. Performed MS analysis: Megumi Nagayama SM DK MH ANN UM NA. Performed statistical analysis: ANN UM SM NA.