About the Authors

Emma A. Webb

Contributed equally to this work with: Emma A. Webb, Michelle A. O’Reilly

Affiliation Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, University College London Institute of Child Health, London, United Kingdom

Michelle A. O’Reilly

Contributed equally to this work with: Emma A. Webb, Michelle A. O’Reilly

Affiliation Neurosciences Unit, UCL Institute of Child Health and Developmental Vision Clinic, Great Ormond Street Children’s Hospital, London, United Kingdom

Jonathan D. Clayden

Affiliation Imaging and Biophysics Unit, University College London Institute of Child Health, London, United Kingdom

Kiran K. Seunarine

Affiliation Imaging and Biophysics Unit, University College London Institute of Child Health, London, United Kingdom

Naomi Dale

Affiliation Neurosciences Unit, UCL Institute of Child Health and Developmental Vision Clinic, Great Ormond Street Children’s Hospital, London, United Kingdom

Alison Salt

Affiliation Neurosciences Unit, UCL Institute of Child Health and Developmental Vision Clinic, Great Ormond Street Children’s Hospital, London, United Kingdom

Chris A. Clark

These authors also contributed equally to this work.

Affiliation Imaging and Biophysics Unit, University College London Institute of Child Health, London, United Kingdom

Mehul T. Dattani

m.dattani@ucl.ac.uk

These authors also contributed equally to this work.

Affiliation Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, University College London Institute of Child Health, London, United Kingdom

Competing Interests

This study was sponsored by The Child Growth Foundation and an unrestricted educational grant from Novo Nordisk Ltd. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Involved in reviewing the manuscript: EAW MO JC KS ND AS CC MTD. Approved the final version of the manuscript: EAW MO JC KS ND AS CC MTD. Conceived and designed the experiments: EAW MO JC ND AS CC MTD. Performed the experiments: EAW MO JC KS. Analyzed the data: EAW MO. Contributed reagents/materials/analysis tools: JC CC. Wrote the paper: EAW.