Polypyrimidine Tract-Binding Protein Induces p19Ink4d Expression and Inhibits the Proliferation of H1299 Cells

Shankung Lin; Ming Jen Wang; Kuo-Yun Tseng

doi:10.1371/journal.pone.0058227

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Open Access

Peer-reviewed

Research Article

Polypyrimidine Tract-Binding Protein Induces p19^Ink4d Expression and Inhibits the Proliferation of H1299 Cells

Shankung Lin ,

* E-mail: shankung@nhri.org.tw

Affiliations Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China, Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, Republic of China
⨯
Ming Jen Wang,

Affiliation Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
⨯
Kuo-Yun Tseng

Affiliation Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China
⨯

Polypyrimidine Tract-Binding Protein Induces p19^Ink4d Expression and Inhibits the Proliferation of H1299 Cells

Shankung Lin,
Ming Jen Wang,
Kuo-Yun Tseng

Published: March 11, 2013
https://doi.org/10.1371/journal.pone.0058227

About the Authors

Shankung Lin

* E-mail: shankung@nhri.org.tw

Affiliations Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China, Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, Republic of China

Ming Jen Wang

Affiliation Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China

Kuo-Yun Tseng

Affiliation Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan, Republic of China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SL. Performed the experiments: MJW KYT. Analyzed the data: SL. Contributed reagents/materials/analysis tools: MJW KYT. Wrote the paper: SL.

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Transfection
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Hyperexpression techniques
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Luciferase
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Messenger RNA
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Cyclins
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Cell proliferation
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DNA synthesis
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Immunoprecipitation
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