IL-1β Promotes Corneal Epithelial Cell Migration by Increasing MMP-9 Expression through NF-κB- and AP-1-Dependent Pathways

Hui-Ching Tseng; I-Ta Lee; Chih-Chung Lin; Pei-Ling Chi; Shin-Ei Cheng; Ruey-Horng Shih; Li-Der Hsiao; Chuen-Mao Yang

doi:10.1371/journal.pone.0057955

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Peer-reviewed

Research Article

IL-1β Promotes Corneal Epithelial Cell Migration by Increasing MMP-9 Expression through NF-κB- and AP-1-Dependent Pathways

Hui-Ching Tseng ,

Contributed equally to this work with: Hui-Ching Tseng, I-Ta Lee

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
⨯
I-Ta Lee ,

Contributed equally to this work with: Hui-Ching Tseng, I-Ta Lee

Affiliations Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan, Department of Anesthetics, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
⨯
Chih-Chung Lin,

Affiliation Department of Anesthetics, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
⨯
Pei-Ling Chi,

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
⨯
Shin-Ei Cheng,

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
⨯
Ruey-Horng Shih,

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
⨯
Li-Der Hsiao,

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
⨯
Chuen-Mao Yang

* E-mail: chuenmao@mail.cgu.edu.tw

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
⨯

IL-1β Promotes Corneal Epithelial Cell Migration by Increasing MMP-9 Expression through NF-κB- and AP-1-Dependent Pathways

Hui-Ching Tseng,
I-Ta Lee,
Chih-Chung Lin,
Pei-Ling Chi,
Shin-Ei Cheng,
Ruey-Horng Shih,
Li-Der Hsiao,
Chuen-Mao Yang

Published: March 7, 2013
https://doi.org/10.1371/journal.pone.0057955

About the Authors

Hui-Ching Tseng

Contributed equally to this work with: Hui-Ching Tseng, I-Ta Lee

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan

I-Ta Lee

Contributed equally to this work with: Hui-Ching Tseng, I-Ta Lee

Affiliations Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan, Department of Anesthetics, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan

Chih-Chung Lin

Affiliation Department of Anesthetics, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan

Pei-Ling Chi

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan

Shin-Ei Cheng

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan

Ruey-Horng Shih

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan

Li-Der Hsiao

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan

Chuen-Mao Yang

* E-mail: chuenmao@mail.cgu.edu.tw

Affiliation Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HCT ITL CMY. Performed the experiments: HCT PLC SEC LDH. Analyzed the data: HCT ITL LDH. Contributed reagents/materials/analysis tools: CCL PLC SEC RHS LDH. Wrote the paper: HCT ITL CMY.

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Cell migration
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Gene expression
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Inflammatory diseases
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