About the Authors

Valeria Capurro

Affiliation Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy

Perrine Busquet

Affiliation Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy

Joao Pedro Lopes

Affiliation Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy

Rosalia Bertorelli

Affiliation Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy

Glauco Tarozzo

Affiliation Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy

Maria Laura Bolognesi

Affiliation Department of Pharmacy and Biotechnology, Bologna University, Bologna, Italy

Daniele Piomelli

Affiliations Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy, Departments of Anatomy and Neurobiology, Pharmacology and Biological Chemistry, University of California Irvine, Irvine, United States of America

Angelo Reggiani

Affiliation Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy

Andrea Cavalli

andrea.cavalli@iit.it

Affiliations Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy, Department of Pharmacy and Biotechnology, Bologna University, Bologna, Italy

Competing Interests

AC and MLB have a patent application for Memoquin (WO03087035 A1 20031023). AC is Editorial Board member. These conflicts of interest do not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: VC PB JPL RB GT AR AC. Performed the experiments: VC PB JPL. Analyzed the data: VC PB JPL RB GT. Wrote the paper: VC PB JPL RB GT MLB DP AR AC.