Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models

Bin Xing; Adam D. Bachstetter; Linda J. Van Eldik

doi:10.1371/journal.pone.0056852

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Peer-reviewed

Research Article

Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models

Bin Xing,

Affiliation Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Adam D. Bachstetter,

Affiliation Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Linda J. Van Eldik

* E-mail: linda.vaneldik@uky.edu

Affiliations Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America, Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯

Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models

Bin Xing,
Adam D. Bachstetter,
Linda J. Van Eldik

Published: February 15, 2013
https://doi.org/10.1371/journal.pone.0056852

About the Authors

Bin Xing

Affiliation Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America

Adam D. Bachstetter

Affiliation Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America

Linda J. Van Eldik

* E-mail: linda.vaneldik@uky.edu

Affiliations Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America, Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BX ADB LVE. Performed the experiments: BX ADB. Analyzed the data: BX ADB LVE. Wrote the paper: BX ADB LVE.

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Microglial cells
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Cytokines
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Neurons
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Central nervous system
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Mouse models
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Neuronal death
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Inflammatory diseases
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MAPK signaling cascades
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