About the Authors

Linong Ji

jiln@bjmu.edu.cn (LJ); s.paul@sph.uq.edu.au (SP)

Affiliation Peking University People's Hospital, Beijing, China

Xiaolin Tong

Affiliation China Academy of Chinese Medicial Sciences Guang'anmen Hospital, Beijing, China

Hongyuan Wang

Affiliation Peking University School of Public Health, Beijing China

Haoming Tian

Affiliation Sichuan University West China Hospital, Chengdu, China

Huimin Zhou

Affiliation The First Hospital of Hebei Medical University, Shijiazhuang, China

Lili Zhang

Affiliation The Third Affiliated Hospital of Peking University of Traditional Chinese and Western Medicine, Beijing, China

Qifu Li

Affiliation The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Yizhong Wang

Affiliation The Central Hospital of China Aerospace Corporation, Beijing, China

Hongmei Li

Affiliation China Meitan General Hospital, Beijing, China

Min Liu

Affiliation The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China

Hongjie Yang

Affiliation Shanghai University of Traditional Chinese Medicine Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China

Yanbin Gao

Affiliation Beijing University of Traditional Chinese Medicine Dongfang Hospital, Beijing, China

Yan Li

Affiliation Zhongshan University Sun Yai-sen Memorial Hospital, Zhongshan, China

Quanmin Li

Affiliation General Hospital of PLA Second Artillery, Beijing, China

Xiaohui Guo

Affiliation Peking University First Hospital, Beijing, China

Gangyi Yang

Affiliation The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

Zhongai Zhang

Affiliation Nanjing Hospital of Traditional Chinese Medicine, Nanjing, China

Zhiguang Zhou

Affiliation The Second Xiangya Hospital of Central South University, Changsha, China

Guang Ning

Affiliation Shanghai Jiaotong University Ruijin Hospital, Shanghai, China

Yingli Chen

Affiliation Peking University People's Hospital, Beijing, China

Sanjoy Paul

jiln@bjmu.edu.cn (LJ); s.paul@sph.uq.edu.au (SP)

Investigators in Evidence-Based Medical Research of Xiaoke Pill Study are listed in Appendix S1.

Affiliation Queensland Clinical Trials and Biostatistics Centre, School of Population Health, University of Queensland, Queensland, Australia

Competing Interests

The authors have declared that no competing interests exist. Several authors have received speaking honoraria from several pharmaceutical companies as follows: Dr. Ji reports receiving consulting and lecture fees from Eli Lilly, Bristol-Myers Squibb, Novartis, Novo Nordisk, Merck, Bayer, Takeda, Sanofi-Aventis, GlaxoSmithKline, Roche, Johnson & Johnson, boehingeringelheim, and Guangzhou Zhongyi Pharmaceutical, and grants from Guangzhou Zhongyi Pharmaceutical and Bayer. Dr. Q Li reports receiving consulting and lecture fees from Eli Lilly, Novo Nordisk, and Sanofi-Aventis. Dr. Tian reports receiving lecture fees from Bristol-Myers Squibb, Novo Nordisk, Bayer, and Sanofi-Aventis. Dr. Y. Li reports receiving consulting fees from Novartis, Novo Nordisk, and Sanofi-Aventis and lecture fees from Novo Nordisk and Sanofi-Aventis. Dr. Guo reports receiving consulting fees from Novartis, Sanofi-Aventis, and Guangzhou Zhongyi Pharmaceutical and lecture fees from Sanofi-Aventis, Guangzhou Zhongyi Pharmaceutical, and Novo Nordisk. Dr. Y. Gao reports receiving consulting fees from Novartis, Sanofi-Aventis, and Guangzhou Zhongyi Pharmaceutical and lecture fees from Sanofi-Aventis, Guangzhou Zhongyi Pharmaceutical, and Novo Nordisk. Dr. M. Liu reports receiving lecture fees from Eli Lilly, Novo Nordisk, and Bayer. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Critically revised the menuscript for important intellectual content: LJ HW HT HZ LZ Qifu Li YW HL ML HY YG YL Quanmin Li XG GY Z. Zhang Z. Zhou GN YC SP Performed the experiments: The Evidence-Based Medical Research of Xiaoke Pill Study Group. Conceived and designed the experiments: LJ XT HT XG ML Qifu Li YL. Performed the experiments: The Evidence-Based Medical Research of Xiaoke Pill Study Investigators. Analyzed the data: LJ YL SP. Contributed reagents/materials/analysis tools: HW SP. Wrote the paper: LJ SP. Critically revised the manuscript for important intellectual content: LJ HW HT HZ LZ Qifu Li YW HL ML HY YG YL Quanmin Li XG GY Z. Zhang Z. Zhou GN YC SP.