About the Authors

Abhiruchi Agarwal

Affiliation Novartis Institute of BioMedical Research, Cambridge, Massachusetts, United States of America

Andreas Boettcher

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Rainer Kneuer

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Farid Sari-Sarraf

Affiliation Novartis Institute of BioMedical Research, Cambridge, Massachusetts, United States of America

Adriana Donovan

Affiliation Novartis Institute of BioMedical Research, Cambridge, Massachusetts, United States of America

Julian Woelcke

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Oliver Simic

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Trixi Brandl

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Thomas Krucker

thomas.krucker@novartis.com

Affiliations Novartis Institute of BioMedical Research, Cambridge, Massachusetts, United States of America, Novartis Institutes of BioMedical Research, Emeryville, California, United States of America

Competing Interests

The authors are, at present, or were during the time of their contribution to this manuscript, employed by Novartis Pharmaceuticals, under the umbrella of the Novartis Institutes for Biomedical Research (NIBR). As such, the authors all own stock in Novartis as part of their remuneration for employment. There are no competing interests as regards consultancies, patents or products in development or currently marketed. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AA TK. Performed the experiments: AA AB FS AD TK. Analyzed the data: AA FS AD JW TK. Contributed reagents/materials/analysis tools: AB RK OS TB. Wrote the paper: AA JW TK.