About the Authors

Eun-Jeong Lee

Current address: Department of Rehabilitation Medicine, College of Medicine, Seoul National University, Seoul, South Korea

Affiliation Department of Physiology, University of Arizona, Tucson, Arizona, United States of America

Josine M. De Winter

Affiliation Institute for Cardiovascular Research, Department of Physiology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands

Danielle Buck

Affiliation Department of Physiology, University of Arizona, Tucson, Arizona, United States of America

Jeffrey R. Jasper

Affiliation Research & Early Development, Cytokinetics, Inc., South San Francisco, California, United States of America

Fady I. Malik

Affiliation Research & Early Development, Cytokinetics, Inc., South San Francisco, California, United States of America

Siegfried Labeit

Affiliation Department of Integrative Pathophysiology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Coen A. Ottenheijm

Affiliations Department of Physiology, University of Arizona, Tucson, Arizona, United States of America, Institute for Cardiovascular Research, Department of Physiology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands

Henk Granzier

Granzier@email.arizona.edu

Affiliation Department of Physiology, University of Arizona, Tucson, Arizona, United States of America

Competing Interests

Two of the co-authors (Drs. Malik and Jasper) are employed by the commercial company (Cytokinetics, Inc) that provided the fast skeletal troponin activator CK-2066260. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EL JDW JRJ FIM SL CAO HG. Performed the experiments: EL JDW DB JRJ CAO. Analyzed the data: EL JDW JRJ FIM SL CAO HG. Contributed reagents/materials/analysis tools: FIM SL. Wrote the paper: EL JRJ FIM SL CAO HG.