About the Authors

Fuyuko Takata

Affiliations Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan, BBB Laboratory, PharmaCo-Cell Co., Ltd., Nagasaki, Japan

Shinya Dohgu

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

Atsushi Yamauchi

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

Junichi Matsumoto

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

Takashi Machida

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

Kayoko Fujishita

Affiliation Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

Keisuke Shibata

Affiliations Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan, Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo, Japan

Youichi Shinozaki

Affiliations Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan, Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo, Japan

Kaoru Sato

Affiliation Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan

Yasufumi Kataoka

Affiliations Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan, BBB Laboratory, PharmaCo-Cell Co., Ltd., Nagasaki, Japan

Schuichi Koizumi

skoizumi@yamanashi.ac.jp

Affiliations Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan, Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo, Japan

Competing Interests

The authors have read the journal's policy and have the following conflicts: in addition to Fukuoka Univ, Drs. Takata and Kataoka are employees of BBB Laboratory, PharmaCo-Cell Co. Ltd., Nagasaki, Japan. The authors declare no financial conflict of interest was present regarding the results or interpretation of the reported experiments. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FT SD YK SK. Performed the experiments: FT SD JM TM KF K. Shibata YS K. Sato. Analyzed the data: FT SD AY. Contributed reagents/materials/analysis tools: FT SD JM TM YK. Wrote the paper: FT SD YK SK.